Proliferative control in Drosophila stem cells
نویسندگان
چکیده
منابع مشابه
Hematopoietic stem cells in Drosophila.
The Drosophila lymph gland, the source of adult hemocytes, is established by mid-embryogenesis. During larval stages, a pool of pluripotent hemocyte precursors differentiate into hemocytes that are released into circulation upon metamorphosis or in response to immune challenge. This process is controlled by the posterior signaling center (PSC), which is reminiscent of the vertebrate hematopoiet...
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The good outcome of hematopoietic stem cell (HSC) transplantation is hampered by low doses of CD34+ cell infusion. Transplanted HSCs undergo a replicative stress that causes accelerated senescence due to rapid telomere shortening. The expansion of human cord blood HSCs is instrumental in obtaining a large number of "good quality" cells, in terms of telomere length and telomerase activity compar...
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Large numbers of granulocytes can be collected repeatedly from the supernatant medium of long-term cultures of mouse bone marrow cells. A constant relationship was found between the number of adherent hematopoietic stem cells and the lifetime cell production per culture. The data indicate that there is a limit to the proliferative capacity of normal and of irradiated stem cells. A similar limit...
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Glaucoma is the leading cause of preventable blindness worldwide. Despite tremendous advances in medical and surgical management of glaucoma in the recent years, the prevalence of glaucoma related blindness is anticipated to increase in the future decades because of the aging population. Stem cells have the potential to change the glaucoma management in several ways. There are several areas of ...
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Background Currently, clinical endodontics includes procedures that are based on the ability of stem cells to accomplish repair (eg, direct pulp capping, apexogenesis, apexification, and even pulpal regeneration). An attempt is made to critically assess the current status in pulp regeneration therapy. Methods: Systematically, 2 distinctly different strategies exist involving stem cells for t...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2008
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2008.10.002